Cellular and molecular mechanisms of glioma pathogenesis
Isolated primary adult human microglia stained with RCA (Green) and Astrocytes stained with GFAP (Red). Nuclei are stained with DAPI (Blue).
Our innate immune system consists of a sophisticated detection mechanism for pathogens and damage called the Nucleotide-binding domain, leucine-rich repeat-containing, proteins (NLRs). Malignant gliomas, the most common primary brain tumors that arise from glial cells within the central nervous system (CNS), are among the most fatal human cancers. With a median survival of only 14.6 months even after aggressive therapy with surgery, radiation, and chemotherapy, most patients succumb to their disease within two years of the initial diagnosis. Gliomas arise from glial cells and are heavily infiltrated with innate immune cells. We are interested in studying the cellular and molecular contribution of NLRs in malignant gliomas.