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Understanding of inflammatory pathways at the nano-bio interface

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Nanoparticles are emerging as an important platform for the manipulation of biological responses in the context of vaccines, cancer therapeutics, modulation of autoimmune diseases, and targeted drug delivery. Considering their widespread applications and increased human exposure it is critical to understand the interaction of these with the human immune system. We are analyzing the size, concentration, and exposure time-dependent effects of amorphous nano-silica on human bronchoalveolar epithelial, endothelial, and fibroblast cell lines. In addition, innate immune regulators associated with nano-silica internalization and subsequent inflammatory pathways are being explored.

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