Inflammation Immunity & Tumour Biology Lab
Unravelling the Role of Neuroinflammation in Epilepsy
Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures. Inflammation is increasingly recognized as a significant factor in the development and progression of epilepsy. Research suggests that neuroinflammation may contribute to the onset of seizures, their recurrence, and the overall pathophysiology of epilepsy. The exact mechanism by which this imbalanced regulation of inflammation causes epilepsy is still unknown. As a result, one of the objectives of epilepsy research is to recognize and clarify the interrelated inflammatory pathways in the systemic and neurological conditions that may promote the progression of epilepsy. Our research focuses on elucidating the cellular and molecular mechanisms of NLR-mediated signalling and its regulation in epilepsy, particularly in the context of antiepileptic drugs. This work aims to develop novel therapeutic strategies for effectively treating drug-refractory epilepsy.