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Understanding dopamine-induced microglial extracellular traps

Primary micro glia -1.tif

Isolated primary adult human microglia stained with RCA (Green) and Astrocytes stained with GFAP (Red). Nuclei are stained with DAPI. 


Dopamine-induced extracellular traps stained with DAPI (Blue) and MPO (Red).

Neutrophils and other innate immune cells can control the spread of pathogens by the formation of extracellular traps (ETs), composed of nuclear and/or mitochondrial DNA. Recently we and others reported the formation of microglia ETs. We reported the formation of microglia ETs in response to dopamine in the BV2 microglia cell line and primary adult human microglia. While neutrophil ETs are crucial for immune surveillance, they are reported to be inflammatory and may lead to pathogenic conditions such as vaso-occlusion, rheumatoid arthritis, and systemic lupus erythematosus. Understanding mechanisms underlying Dopamine-induced microglia ETs may lead to better understanding of sterile inflammation in the CNS. 

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